| Brixton Brewing | 165 Brighton Ave | Rochester | Pennsylvania | 15074-2203 | United States | brewpub | |
| Broken Chair Brewery | 424 East Penn Ave | West Reading | Pennsylvania | 19611-1130 | United States | micro | |
| Broken Goblet Brewing | 1500 Grundy Ln Bldg 1 | Bristol | Pennsylvania | 19007-1521 | United States | brewpub | |
| Bubes Brewery | 102 N Market St | Mount Joy | Pennsylvania | 17552-1306 | United States | brewpub | |
| Bucks County Brewery | 31 Appletree Ln | Pipersville | Pennsylvania | 18947-1083 | United States | micro | |
| Bullfrog Brewery | 229 W 4th St | Williamsport | Pennsylvania | 17701-6112 | United States | brewpub | |
| Bullfrog Brewery - Production Only | 229 W 4th St | Williamsport | Pennsylvania | 17701-6112 | United States | micro | |
| Buon Appetito Ristorante | 6147 York Rd | Spring Grove | Pennsylvania | 17362-9120 | United States | brewpub | |
| Burghâers Brewing | 22410 Perry Hwy Ste 410E | Zelienople | Pennsylvania | 16063-2935 | United States | micro | |
| Butler Brew Works | 101 S Main St | Butler | Pennsylvania | 16001-5907 | United States | brewpub | |
| Cave Brewing Co | 1407 Seidersville Rd | Bethlehem | Pennsylvania | 18015-4219 | United States | micro | |
| Cellar Works Brewing Co. | 110 S Pike Rd Ste 205 | Sarver | Pennsylvania | 16055-9682 | United States | micro | |
| Center Square Brewing / Altland House | 1 Center Sq | Abbottstown | Pennsylvania | 17301-9502 | United States | brewpub | |
| Chatty Monks Brewing Company | 610 Penn Ave | West Reading | Pennsylvania | 19611-1004 | United States | brewpub | |
| Church Brew Works/Lawrenceville Brewery Inc. | 3525 Liberty Ave | Pittsburgh | Pennsylvania | 15201-1324 | United States | brewpub | |
| Cinderlands Beer Co. | 3705 Butler St | Pittsburgh | Pennsylvania | 15201-1819 | United States | brewpub | |
| Clarion River Brewing Company | 600 Main St # 604 | Clarion | Pennsylvania | 16214-1108 | United States | brewpub | |
| Coal Country Brewing | 625 W High St | Ebensburg | Pennsylvania | 15931 | United States | micro | |
| Coal Tipple Brewery / Kramer Farms | 1905 Steubenville Rike | Burgettstown | Pennsylvania | 15021 | United States | micro | |
| Cobblehaus Brewing Company | 1021 5th Ave | Coraopolis | Pennsylvania | 15108-1803 | United States | micro | |
| Collusion Tap Works | 105 S Howard St | York | Pennsylvania | 17401-2001 | United States | brewpub | |
| Columbia Kettle Works | 40 N 3rd St | Columbia | Pennsylvania | 17512-1104 | United States | brewpub | |
| Conny Creek Brewing Co | 4323 Shearsburg Rd | New Kensington | Pennsylvania | 15068-6845 | United States | micro | |
| Conshohocken Brewing - Bridgeport | 3 DeKalb St | Bridgeport | Pennsylvania | 19405-1074 | United States | brewpub | |
| Conshohocken Brewing Co. | 739 E Elm St Ste B | Conshohocken | Pennsylvania | 19428-2301 | United States | brewpub | |
| Conyngham Brewing Company | 309 Main St | Conyngham | Pennsylvania | 18219-0910 | United States | micro | |
| Copper Kettle Brewing Co | 557 Greenfield Ave | Pittsburgh | Pennsylvania | 15207-1093 | United States | micro | |
| CoStar Brewing Inc. | 919 N Saint Clair St | Pittsburgh | Pennsylvania | 15206-2133 | United States | micro | |
| Couch Brewery | 1351 Washington Blvd | Pittsburgh | Pennsylvania | 15206-1801 | United States | micro | |
| Covered Bridge Brewhaus Taproom | 506 N 8th St | Shamokin | Pennsylvania | 17872-5302 | United States | micro | |
| CR Brewing Company | 3009 Wilmington Rd | New Castle | Pennsylvania | 16105 | United States | brewpub | |
| Crime & Punishment Brewing Company | 2711 W Girard Ave | Philadelphia | Pennsylvania | 19130-1212 | United States | brewpub | |
| Crooked Eye Brewery | 13 E Montgomery Ave Ste 2 | Hatboro | Pennsylvania | 19040-2618 | United States | micro | |
| Crooked Tongue Brewing | 2516 Benjamin Franklin Hwy | Edinburg | Pennsylvania | 16116-4302 | United States | micro | |
| Crowded Castle Brewing Co. Inc. | 242 Bridge St | Phoenixville | Pennsylvania | 19460-3450 | United States | brewpub | |
| Crystal Ball Brewing | 1612 W King St | York | Pennsylvania | 17404-5618 | United States | micro | |
| Curran Brewing Co | 6230 Bloomington Rd | Moscow | Pennsylvania | 18444-6634 | United States | micro | |
| D. G. Yuengling and Son Inc | 500 Mahantongo St | Pottsville | Pennsylvania | 17901 | United States | regional | |
| D. G. Yuengling and Son Inc | 310 Mill Creek Ave | Pottsville | Pennsylvania | 17901-8692 | United States | regional | |
| Dancing Gnome Beer | 925 Main St | Pittsburgh | Pennsylvania | 15215-2301 | United States | micro | |
| Daugherty Brewing Company | | Erie | Pennsylvania | 16510-3680 | United States | planning | |
| Depot Saloon | 9 S Race St | Greenville | Pennsylvania | 16125-2213 | United States | brewpub | |
| Desperate Times Brewing Co | 1201 Carlisle Springs Rd | Carlisle | Pennsylvania | 17013-1554 | United States | brewpub | |
| Devout Brewing | | Export | Pennsylvania | 15632 | United States | planning | |
| Divine Swine BBQ | 2684 Lebanon Rd | Manheim | Pennsylvania | 17545-9524 | United States | brewpub | |
| Doc G's Brewing Company | 208 W Long Ave | Du Bois | Pennsylvania | 15801-2106 | United States | brewpub | |
| Dock Street Brewery | 701 S 50th St Fl 1 | Philadelphia | Pennsylvania | 19143-1689 | United States | brewpub | |
| Dock Street Brewing Co | | Philadelphia | Pennsylvania | 19146 | United States | planning | |
| Double D Brewing / Dommy's Pizza | 1100 Hancock Ave | Vandergrift | Pennsylvania | 15690-2061 | United States | brewpub | |
| Doylestown Brewing Co | 52 East State St. | Doylestown | Pennsylvania | 18901 | United States | proprietor | |